Many of the sites Xponent produces are built upon modifications of themes dependent on Genesis. To work this way is very cost effective, that is, if you can find a theme with the appropriate functionality and looks the client are asking for.
Some clients, on the other hand, need a theme that is made from the ground up. This might be because of design ideas, or just the urge to own some originality, or the need for some functionality that must be designed in detail. When a customer ask for an original design we still rely upon the Genesis Framework, here are a few links to original designed sites we made for customers and three more of our designs made for general use when a customer need a premade theme that we add a few tweaks to.